Toronto FC fell to Orlando City on American Independence Day, dropping a 4-0 result in Florida.
In his second match in charge, Interim Head Coach Terry Dunfield made two changes to the team that dropped a 1-0 result to Real Salt Lake on Saturday night, with Alonso Coello and Ayo Akinola coming into the side as Lorenzo Insigne and CJ Sapong made way.
Orlando struck for two goals on either side of halftime with four different goal-scorers on the night.
Captain Federico Bernardeschi saw red in 62nd minute, reducing TFC to 10 men for the final half hour.
The Reds return to action on Saturday, July 8 to host expansion side St. Louis CITY SC for the first time.